County outline
Where Issaquena County is located
Area breakdown
Land accounts for 93.6% of Issaquena County’s measured area and water for 6.4%. Its combined area converts to 1,143.3 square kilometers or approximately 282,510 acres.
Green: land · blue: water
| Measurement | Square miles | Square kilometers | Acres |
|---|---|---|---|
| Land | 412.98 | 1,069.613 | 264,307.2 |
| Water | 28.442 | 73.664 | 18,202.9 |
| Total | 441.422 | 1,143.278 | 282,510.1 |
How Issaquena County compares
By original Census land area, Issaquena County ranks #73 of 82 in Mississippi and #2448 of 3,222 nationally. National rankings include the 50 states, District of Columbia, and Puerto Rico.
Its land area is 0.728 times the Mississippi county-equivalent median of 567 square miles. It accounts for 0.9% of the combined county land area in the state.
See the complete Mississippi ranking · What counts as a county equivalent?
Population and density of Issaquena County
The Census Bureau estimates that 1,263 people lived in Issaquena County on July 1, 2025. That ranks #3,171 of 3,222 county equivalents nationally and #82 of 82 in Mississippi. Since the April 1, 2020 estimates base of 1,337, the population has declined by 74 (−5.5%), compared with −0.2% for Mississippi as a whole.
With 413 square miles of land, that is 3.1 people per square mile (1.2 per km²), placing Issaquena County #2,976 nationally for density and #82 in Mississippi. The median county equivalent has 47 people per square mile; the Mississippi median is 43. Put another way, there are about 209 acres of land per resident.
| July 1 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|---|
| Estimate | 1,326 | 1,318 | 1,281 | 1,273 | 1,288 | 1,263 |
| Change | — | −8 | −37 | −8 | +15 | −25 |
U.S. Census Bureau, Vintage 2025 population estimates. Estimates are revised each year and are not decennial census counts. Density divides the whole population by the whole county’s land area, so it describes an average, not how settlement is distributed within the county. Population sources and methods.
Cities and towns in Issaquena County
1 incorporated place lies at least partly in Issaquena County. Together they are home to 453 people (35.9%); the other 810 (64.1%) live outside any incorporated place, in unincorporated communities and rural areas.
The largest is Mayersville town, with 453 residents in the county.
Metropolitan area
Issaquena County is not part of any metropolitan or micropolitan statistical area in the Office of Management and Budget’s July 2023 delineation; 1,306 other county equivalents are also outside one. These areas are built around an urban core of at least 10,000 people plus the counties tied to it by commuting, so counties outside them are generally rural.
ZIP codes
6 ZIP Code Tabulation Areas have land in Issaquena County; 3 of them have most of their land inside the county, and the others mainly cover neighboring areas.
387443874539113391593917739183
ZIP Code Tabulation Areas are the Census Bureau’s approximations of USPS ZIP Code service areas, from the 2020 Census relationship files. Lighter codes have less than half of their land in this county. Post-office-box and single-address ZIP Codes have no tabulation area.
Counties bordering Issaquena County
Issaquena County shares a land border with 6 county equivalents, including 2 in Louisiana and Arkansas. Each of them has more land than Issaquena County. The largest neighbor is Yazoo County (922.3 mi²) and the smallest is East Carroll Parish (421.2 mi²). Together with its neighbors, Issaquena County forms a block of 4,137.9 mi² of land, of which it holds 10%.
| Bordering county equivalent | Land mi² | Size vs. Issaquena | Compare |
|---|---|---|---|
| Yazoo County | 922.3 | 2.2× larger | Compare |
| Washington County | 724.1 | 1.8× larger | Compare |
| Chicot CountyArkansas | 637 | 1.5× larger | Compare |
| Warren County | 588.5 | 1.4× larger | Compare |
| Sharkey County | 431.7 | about the same | Compare |
| East Carroll ParishLouisiana | 421.2 | about the same | Compare |
How big is Issaquena County compared with U.S. states?
Issaquena County has less land than any of the 50 states. Rhode Island, the smallest state by land area, has 1,033.9 mi², about 2.5 times as much. Mississippi’s county land could hold about 114 areas the size of Issaquena County.
Another way to picture it: the same land area would fill a square about 20.3 miles (32.7 km) on each side. Real county shapes are rarely square, so this is a scale reference rather than a width or driving distance.
State figures are the sums of each state’s county-equivalent land measurements in the same Census release, so states and counties are compared on the same basis. Published state totals can differ slightly because of rounding. Compare all states · Counties bigger than entire states.
What stands out about Issaquena County?
Issaquena County has more land than 774 of the other 3,221 county equivalents in the dataset.
A median is the middle county-equivalent measurement, not the average of the largest and smallest. All three bars use the same linear scale. Very small areas may appear as a thin sliver; the labels retain their values.
Does including water change its rank?
Using land plus water places Issaquena County at #2,383 nationally by total area, 65 places closer to the top than its land rank. The water assigned to this geography moves it ahead of some county equivalents with more land.
Its water share is 6.4%, compared with a national county-equivalent median of 1.2% — 5.3 percentage points higher. This describes the statistical geography’s land/water mix, not flood exposure or developable land.
Closest positions in the national land ranking
These entries sit immediately beside Issaquena County in the national ranking. They can be in different states and are not necessarily geographic neighbors.
| Land rank | County equivalent | Land mi² | Comparison |
|---|---|---|---|
| #2447 | Frederick County, Virginia | 413.1 | Compare |
| #2448 | Issaquena County, Mississippi | 413 | This county |
| #2449 | Naugatuck Valley Planning Region, Connecticut | 412.8 | Compare |
Calculated from the same Census release as the area table. Total-area order uses original ALAND + AWATER; water shares and chart labels use published square miles. Calculation details.
Representative coordinates
The Census internal point is 32.755539, -91.003535. It represents a location inside the geography; it is not necessarily the centroid or the address of a courthouse.
Source and precision
U.S. Census Bureau, 2026 Gazetteer Files, Counties. Original ALAND: 1,069,614,268 m²; AWATER: 73,664,788 m². Rankings use ALAND; exact ties use ascending GEOID. Tables preserve Census-published square miles to three decimals, with conversions based on those values.
Common questions
How big is Issaquena County?
Issaquena County, Mississippi has 413 square miles (1,069.6 km²) of land and 28.4 square miles of water, for a total area of 441.4 square miles. It ranks #2448 of 3,222 U.S. county equivalents by land area.
Is Issaquena County the largest county in Mississippi?
No. Issaquena County ranks #73 of 82 in Mississippi by land area. The largest is Yazoo County, with 922.3 square miles of land.
What counties border Issaquena County?
Issaquena County shares a land border with East Carroll Parish, Louisiana, Warren County, Sharkey County, Washington County, Yazoo County, and Chicot County, Arkansas.
What is the population of Issaquena County?
The Census Bureau estimates Issaquena County had 1,263 residents on July 1, 2025, ranking #3,171 of 3,222 county equivalents. That is 3.1 people per square mile of land.
What is the county seat of Issaquena County?
The county seat of Issaquena County is Mayersville.
Is Issaquena County part of a metropolitan area?
No. Issaquena County is outside every metropolitan and micropolitan statistical area in the July 2023 OMB delineation.
How many ZIP codes are in Issaquena County?
6 ZIP Code Tabulation Areas have land in Issaquena County, and 3 of them have most of their land inside the county. Census ZIP Code Tabulation Areas approximate USPS ZIP Code areas.
How does Issaquena County compare with U.S. states?
It has less land than every state. Rhode Island, the smallest, has 2.5 times as much land.
How many acres of land are in Issaquena County?
The land measurement converts to approximately 264,307 acres. Including water, total area is approximately 282,510 acres. One square mile equals 640 acres.
Why might another source show a different area?
Check whether it reports land or total area, its Census vintage, and its rounding. Our guide explains how to reconcile county area figures.
Can this establish a property boundary?
No. Statistical measurements and generalized maps do not establish property lines. Consult the relevant local surveying or land-records authority.